郭忠新教授，博士生导师,糖果派对、海峡联合研究院、媒介病毒研究中心，教授，博士生导师。2022福建省高层次人才（B类），2020福建省百人计划， 2018福建省“闽江学者”特聘教授。美国UNIVERSITY OF OKLAHOMA-Norman 植物生物学博士，导师Prof. Jia Li。美国UNIVERSITY OF CALIFORNIA-RIVERSIDE 丁守伟教授实验室博士后和PURDUE UNIVERSITY 朱健康院士实验室博士后。研究成果发表在《Nature Reviews Immunology》、《PNAS》、《Plant Cell》、《Plant Physiology》、《PLOS Pathogens》、《Horticulture Research》、《NATURE COMMUNICATION》等国际一流期刊。
研究方向：拟南芥、番茄和水稻中RNA干扰（RNAi）介导的抗病毒免疫的作用机理和应用。
病毒是一种严重危害人类和动植物健康的病原菌。RNAi介导的植物抗病毒免疫是真核生物中一种保守的、广谱的天然抗病毒免疫，而且几乎对所有的动植物病毒都起作用。我们实验室创立一种高效的遗传筛选体系来分离植物抗病毒RNAi免疫缺陷突变体，筛选到了一系列植物突变体，通过突变体发掘多个植物抗病毒RNAi新基因，并通过遗传学、分子生物学和生物化学、细胞生物学和生物信息学等方法揭示了这些基因的抗病毒作用机理。我们将通过挖掘更多的抗病毒RNAi新基因，深入阐明抗病毒RNAi的作用机理，并进一步探索其在防治动植物病毒病甚至人类病毒病中的实践应用。
联系方式：Email zhongxin5919@163.com
人才计划和科研项目：
n 福建省B类高层次人才，2022。
n 福建省百人计划，2020。
n 福建省闽江学者特聘教授，2018。
n 中国自然科学基金面上项目（批准号：31870146）,“利用一种高效遗传筛选研究RNAi介导的植物抗病毒免疫”，2019。
n 福建省基金重点项目，“番茄中RNAi介导的植物抗病毒作用机理及应用的研究”，2020。
发表论文：
l Zhao LL, Chen YF, Xiao XM, Gao HY, Cao JM, Zhang ZK, Guo ZX. (2023) AGO2a but not AGO2b mediates antiviral defense against the infection of wildtype Cucumber mosaic virus in tomato, Horticulture Research, uhad043, https://doi.org/10.1093/hr/uhad043 (online).
l Yan W, Zhu Y, Liu W, Zou C, Jia B, Chen ZQ, Han Y, Wu J, Yang DL, Zhang Z, Xie L, Chen B, Li R, Ding S-W, Wu Q, Guo ZX. (2023) Discovery of aphid-transmitted rice tiller inhibition virus from native plants by small RNA sequencing, PLOS Pathogens (accepted).
l Xu Q, Shen L, Jin L, Wang M, Chang F, Guo ZX. (2022). Comparative transcriptome analysis of CMV or 2b-deficient CMV-Infected dcl2dcl4 reveals the effects of viral infection on symptom induction in Arabidopsis thaliana. Viruses, 14(7), 1582.
l Liying Jin, Mengna Chen, Meiqin Xiang, Zhongxin Guo. (2022) RNAi-based antiviral innate immunity in plants, Viruses, 14, 432.
l Zhongxin Guo, Yang Li, Shou-Wei Ding. (2019) Small RNA-based antimicrobial immunity, Nature Reviews Immunology, 19, 31-44.
l Zhongxin Guo, Xian-Bing Wang, Wan-Xiang Li, and Shou-Wei Ding. (2019) A sensitized genetic screen to identify novel components and regulators of the host antiviral RNA interference pathway. Methods of Molecular Biology, 2028: 215-229.
l Zhongxin Guo, Jinfeng Lu, Xianbing Wang, Wanxiang Li, Shou-Wei Ding. (2017) Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis. Proc Natl Acad Sci U S A 114, 1377-1382.
l Zhongxin Guo*, Xianbing Wang*, Ying Wang, Wanxiang Li, Amit Gal-On, Shou-Wei Ding. (2018) Identification of a new host factor required for antiviral silencing and amplification of viral siRNAs. Plant Physiology, 176, 1587-1597.
l Zhongxin Guo, Shozo Fujioka, Sen Miao, Blancaflor Elison, Xiaoping Gou, Jia Li. (2010) TCP1 modulates Brassinosteroid biosynthesis by regulating the expression of the key biosynthetic enzyme gene DWARF4 in Arabidopsis thaliana. Plant Cell, 22, 1161-1173.
l Qingfeng Niu# , Zhe Song# , Kai Tang, Lixian Chen, Lisi Wang, Ting Ban, Zhongxin Guo, Chanhong Kim, Heng Zhang, Cheng-Guo Duan, Huiming Zhang, Jian-Kang Zhu, Jiamu Du* , Zhaobo Lang* . (2021) A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation. Nature Communication, 12(1):3367.
l Zhong-Qi Chen, Jian-Hua Zhao, Qian Chen, Zhong-Hui Zhang, Jie Li, Zhongxin Guo, Qi Xie, Shou-Wei Ding, Hui-Shan Guo* . (2020) DNA Geminivirus Infection Induces an Imprinted E3 Ligase Gene to Epigenetically Activate Viral Gene Transcription. Plant Cell, 32(10):3256-3272.
l Kezhi Zheng, Lili Wang, Longjun Zeng, Dachao Xu, Zhongxin Guo, Xiquan Gao, Dong-Lei Yang* . (2021) The effect of RNA polymerase V on 24-nt siRNA accumulation depends on DNA methylation contexts and histone modifications in rice. PNAS, 118(30):e2100709118.
l An J, Guo Z, Gou XP, Li, J. (2011) TCP1 positively regulates the expression of DWF4 in Arabidopsis thaliana. Plant signaling & Behavior, 6: 1117-1118.
l He K, Gou X, Powell RA, Yang H, Yuan T, Guo Z, Li J. (2008) Receptor-like protein kinases, BAK1 and BKK1, regulate a light-dependent cell-death control pathway. Plant Signaing &l Behavior, 3:813-5.
会议报告：
l 郭忠新, Phospholipids regulates RNAi-mediated antiviral innate immunity in Arabidopsis. 中国生物化学和分子生物学年会，海南师范大学，海南海口，2020年12月5日-7日。
l 郭忠新. Dissect small RNA-based antiviral immunity in plants, 中国植物生理和植物分子生物学学会第十二次会员代表大会暨全国学术年会，江西南昌, 2019年7月5日-8日。
l 郭忠新. Phospholipid controls small RNA-mediated antiviral innate immunity in Arabidopsis, 中国植物病理学病毒专业委员会与生物技术专业委员会2018年学术年会,山东泰安, 2018年10月15日-18日。
l Zhongxin Guo. Identification, cloning and characterization of a host gene required for antiviral RNA interference by a forward genetic screen in Arabidopsis thaliana, 35th American Society for Virology Annual meeting, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. 2016 June 18-22.
l Zhongxin Guo. Membrane proteins regulate viral immunity by controlling viral siRNA production in Arabidopsis. 95th AAAS Pacific Division Annual Meeting, University of California, Riverside, California, USA. 2014 June 17-20.
